SDS Seminar Series – Dr. Emily Roberts
Sep
8
2023
Sep
8
2023
Description
The Fall 2023 SDS Seminar Series beings on September 8th from 2:00 p.m. to 3:00 p.m. with Dr. Emily Roberts (Department of Biostatistics, University of Iowa). This event is in-person.
Title: A Causal Inference Approach for Surrogate Marker Evaluation with Mixed Models
Abstract: In randomized clinical trials, intermediate endpoints may serve as surrogate markers for a clinical outcome of interest. Before taking advantage of such a surrogate, it is critical to carefully determine whether a candidate marker is valid for use in a future trial. This work builds on established causal inference approaches for evaluating a candidate surrogate using potential outcomes when measures of both outcomes are repeatedly collected. We do so by using the principal stratification framework and linear mixed models. This proposed framework allows us to calculate a causal effect predictiveness curve based on the distribution of random effects for both the surrogate and clinical endpoints and observed and counterfactual outcomes. Our work is primarily motivated by a diabetes clinical trial which investigated a potential treatment to protect beta cells in new onset Type 1 Diabetes patients.
Location
Moffett Molecular Biology Building (MBB) 1.210
Share
Other Events in This Series
Sep
12
2025
SDS Seminar Series – Lydia Lucchesi, University of Texas at Austin
Visual Documentation for Data Preprocessing in R and Python
2:00 pm – 3:00 pm • In Person
Speaker(s): Lydia Lucchesi
Sep
19
2025
SDS Seminar Series – Tuan Pham, University of Texas at Austin
Time-uniform Bounds for Iterated Algorithms
2:00 pm – 3:00 pm • In Person
Speaker(s): Tuan Pham
Sep
26
2025
SDS Seminar Series - Ryan Giordano, University of California, Berkeley
Local Weighting--Based Diagnostics for Bayesian Multilevel Regression with Poststratification
2:00 pm – 3:00 pm • In Person
Speaker(s): Ryan Giordano
Oct
3
2025
SDS Seminar Series – Rafael Campello de Alcantara, University of Texas at Austin
Searching for Parallel Trends: A Decision Tree Algorithm for Discovering Conditional Diff-in-Diff Estimators
2:00 pm – 3:00 pm • In Person
Speaker(s): Rafael Campello de Alcantara
Oct
10
2025
SDS Seminar Series – Michele Guindani, University of California, Los Angeles
Embracing Heterogeneity: Bayesian Clustering Methods for Neuroscience Data
2:00 pm – 3:00 pm • In Person
Speaker(s): Michele Guindani
Oct
17
2025
SDS Seminar Series – Wenyi Wang, MD Anderson Cancer Center
Deciphering Tumor Heterogeneity for Benefits from Immunotherapy in Cancer
2:00 pm – 3:00 pm • In Person
Speaker(s): Wenyi Wang
Oct
24
2025
SDS Seminar Series - Jonathan Huggins, Boston University
Robust Model Selection for Discovery of Latent Mechanistic Processes
2:00 pm – 3:00 pm • In Person
Speaker(s): Jonathan Huggins
Oct
31
2025
SDS Seminar Series – Max Goplerud, University of Texas at Austin
Generalized Bilinear Mixed Models and Variational Inference
2:00 pm – 3:00 pm • In Person
Speaker(s): Max Goplerud
Nov
7
2025
SDS Seminar Series – Jeffrey Miller, Harvard University
Bayesian Model Criticism Using Uniform Parametrization Checks
2:00 pm – 3:00 pm • In Person
Speaker(s): Jeffrey Miller
